The Male Factor in Recurrent Miscarriage
Understanding men’s role in recurrent pregnancy loss (RPL)
Experiencing recurrent pregnancy loss (RPL) -defined as two or more miscarriages- is devastating, and we want you to know you are not alone. While RPL is often investigated through the female partner, increasing evidence shows that sperm DNA damage plays a significant and often overlooked role.
Identifying the male factor through specialised testing is a crucial step toward finding answers and determining the right treatment pathway.
Sperm DNA fragmentation’s link to Miscarriage
Sperm DNA is the most important part of the sperm. It contains the genetic instructions for the baby. This DNA can be damaged during sperm production and transport. This is known as Sperm DNA Fragmentation (SDF).
High levels of SDF have been shown to double the likelihood of a miscarriage occurring (Source: Men and Miscarriage Research).
Examen’s research shows that sperm from men whose partners have a history of miscarriage have significantly higher levels of sperm DNA fragmentation than those who deliver healthy babies. We have observed high sperm DNA damage in over 85% of men whose partners had recurrent miscarriages. This was true for couples who conceived naturally as well as those who conceived with fertility treatment.
General SDF Damage
Caused by lifestyle factors (stress, smoking, obesity).
Double-Strand Breaks (dsDB)
Severe damage to both DNA strands.
This specific, severe damage is particularly detrimental and strongly linked to recurrent miscarriage.
The Extend® test
Extend was developed specifically focusing on dsDB fragmentation damage only. This unique measurement provides the critical piece of information needed to assess the male partner’s risk and determine the most effective treatment.
It is highly recommended that Extend be ordered and interpreted by a specialist (a Fertility Consultant, Andrologist, or Urologist).
Ready for answers?
If you have experienced two or more miscarriages, the Extend® provides a critical piece of information needed to move forward.