Our mission is to improve the diagnosis and management of male infertility – helping clinicians deliver better care for couples and individuals on their fertility journeys. This section provides Healthcare Professionals with the latest clinical evidence and resources to support informed patient care.
Examen’s SDF Tests, Powered by SpermComet®
Our Sperm DNA Fragmentation (SDF) tests are powered by our ISO-accredited SpermComet® technology, which applies a highly sensitive technique called single-cell gel electrophoresis. This method gently unwinds the tightly packed DNA within each sperm cell so that any DNA fragmentation present can be directly measured.
Exact® Test: The Comprehensive Diagnostic
The Exact test is a comprehensive diagnostic tool that measures the level of total sperm DNA fragmentation, including both single- and double-strand breaks.
It is important for identifying the underlying cause of male infertility. While other tests only estimate susceptibility to DNA damage, Exact provides a direct measurement of the DNA damage itself – making it the most accurate and clinically useful test for Total SDF damage.
Key Clinical Applications:
- Diagnose infertility: Identify hidden DNA damage in men with a normal semen analysis.
Key Clinical Applications:
- Recurrent miscarriage: Our published research shows high levels of dsDB are associated with repeated pregnancy loss (RPL), highlighting the male factor contribution to RPL.
- Predicting IVF or Live Birth Outcome: Our published research shows that higher dsDB levels are linked to lower IVF live birth outcomes, highlighting the male factor contribution to successful IVF live birth outcome.
Extend® Test: The Recurrent Miscarriage Specialist
The Extend test is the only commercially available fertility test that exclusively measures double-strand DNA breaks (dsDB).
Unlike single-strand SDF damage, dsDBs originate during spermatogenesis (during the process of sperm production in the testes).
dsDBs cannot be repaired by the sperm itself – repair depends entirely on the female egg, and this capability to repair dsDBs declines as female egg age advances.
Sperm DNA Fragmentation:
A Better Biomarker
Conventional semen analysis is accepted to have limited diagnostic value for male infertility and poor prognostic value for ART success.
In contrast, sperm DNA fragmentation has been shown to be a robust biomarker of male infertility, IVF failure, and miscarriage.
Research Library
An extensive research library for Healthcare Professionals to support the management of their male patients.